Description

2-(2-Chloro-3-(Trifluoromethoxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its value lies in enabling efficient, selective cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This advanced intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly in the development of novel active ingredients. The compound is supplied with a guaranteed CAS No. 870822-81-4 to ensure precise identification and supply chain integrity.

Application

This versatile boronic ester is a key reagent in several high-value chemical synthesis pathways:

• Suzuki-Miyaura Cross-Coupling Reactions: Primarily used as a coupling partner with aryl/heteroaryl halides to form biaryl and heterobiaryl structures, a cornerstone reaction in medicinal chemistry.
• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, especially those containing trifluoromethoxy-substituted aromatic systems.
• Agrochemical Synthesis: Employed in the research and production of advanced herbicides, fungicides, and insecticides where the specific chlorotrifluoromethoxy phenyl moiety imparts desired biological activity.
• Material Science Research: Used in the development of organic electronic materials, such as OLEDs and semiconductors, where precise control over molecular structure is required.
• Ligand and Catalyst Development: Acts as a precursor for creating novel bidentate ligands or functionalized catalysts for asymmetric synthesis.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes for studying biological processes and target identification.

Basic Information

Item	Details
Product Name	2-(2-Chloro-3-(Trifluoromethoxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	870822-81-4
Molecular Formula	C13H15BClF3O3
Molecular Weight	322.52 g/mol
Synonyms	2-Chloro-3-(trifluoromethoxy)phenylboronic acid pinacol ester; (2-Chloro-3-(trifluoromethoxy)phenyl)boronic acid pinacol ester; 2-(2-Chloro-3-(trifluoromethoxyphenyl))-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol (2-Chloro-3-(trifluoromethoxy)phenyl)boronate; 2-Chloro-3-trifluoromethoxyphenylboronic acid pinacol ester; 870822-81-4; Boronic acid, B-[2-chloro-3-(trifluoromethoxy)phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our production of 2-(2-Chloro-3-(Trifluoromethoxy)Phenyl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane adheres to stringent quality management protocols. Each batch undergoes comprehensive analytical characterization using techniques including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting key parameters such as assay purity and impurity profiles. Our quality systems are designed to support cGMP compliance for pharmaceutical applications, ensuring traceability and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizers and bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Typical 98-99%)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.