Description

4-Bromo-5-Fluoro-2-Iodotoluene is a high-value, multi-halogenated aromatic building block essential for advanced organic synthesis. Its unique substitution pattern makes it a critical intermediate for constructing complex molecular architectures, particularly in pharmaceutical and agrochemical research. This compound is primarily sought after by R&D chemists and process development scientists working on novel active ingredients, including kinase inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug candidates, especially kinase inhibitors and other targeted therapies.
• Agrochemical Research: Used to develop novel herbicides, fungicides, and insecticides with specific modes of action.
• Material Science: Serves as a building block for advanced organic electronic materials and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and Negishi cross-coupling reactions due to the reactive iodine and bromine substituents.
• Functional Group Transformation: Utilized in sequential functionalization strategies to introduce diverse chemical handles onto the aromatic core.
• Chemical Biology: Employed in the synthesis of molecular probes and labeled compounds for biological studies.

Basic Information

Product Name	4-Bromo-5-Fluoro-2-Iodotoluene
CAS No.	870704-15-7
Molecular Formula	C7H5BrFI
Molecular Weight	314.92 g/mol
Synonyms	1-Bromo-4-fluoro-2-iodo-5-methylbenzene; 2-Iodo-4-bromo-5-fluorotoluene; 5-Fluoro-4-bromo-2-iodotoluene; Toluene, 4-bromo-5-fluoro-2-iodo-; 4-Bromo-5-fluoro-2-iodo-1-methylbenzene; 2-Iodo-5-fluoro-4-bromotoluene
EINECS	Contact for details

Quality Control

Our 4-Bromo-5-Fluoro-2-Iodotoluene is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, guaranteeing traceability and compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.