Description

Ethyl 6-Trifluoromethoxyindole-2-Carboxylate is a high-value, synthetically versatile indole derivative, serving as a critical building block in advanced organic synthesis. Its molecular architecture, featuring both indole and trifluoromethoxy moieties, makes it indispensable for constructing complex molecules with tailored biological and physicochemical properties. This compound is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Research: Used in the development of new-generation pesticides and herbicides, where the trifluoromethoxy group can enhance metabolic stability and bioavailability.
• Material Science: Serves as a monomer or functional additive in the creation of specialty polymers and organic electronic materials.
• Chemical Biology: Employed as a probe or labeling reagent in biochemical assays and diagnostic research due to its unique fluorinated structure.
• Academic & Process Chemistry: A valuable substrate for methodological development in organic synthesis, including cross-coupling and heterocyclic chemistry.

Basic Information

Product Name	Ethyl 6-Trifluoromethoxyindole-2-Carboxylate
CAS No.	870536-88-2
Molecular Formula	C₁₂H₁₀F₃NO₃
Molecular Weight	273.21 g/mol
Synonyms	Ethyl 6-(Trifluoromethoxy)-1H-indole-2-carboxylate; 6-Trifluoromethoxyindole-2-carboxylic Acid Ethyl Ester; 1H-Indole-2-carboxylic acid, 6-(trifluoromethoxy)-, ethyl ester; Ethyl 6-(trifluoromethoxy)indole-2-carboxylate; 2-Carbethoxy-6-trifluoromethoxyindole; Ethyl 6-trifluoromethoxy-1H-indole-2-carboxylate; CAS 870536-88-2
EINECS	Contact for details

Quality Control

Our Ethyl 6-Trifluoromethoxyindole-2-Carboxylate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting critical parameters such as assay, impurity profile, and residual solvents. Our quality commitment supports applications in GMP and cGMP environments where reliable sourcing is paramount.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept sealed and under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.