Description

3-(2-Methoxyphenyl)-1,1,1-Trifluoro-2-Propanone is a specialized fluorinated aromatic ketone building block of significant interest in advanced organic synthesis. Its unique trifluoromethyl ketone moiety adjacent to a methoxy-substituted phenyl ring makes it a valuable precursor for creating complex molecules with tailored properties. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, due to its structural motif.
• Agrochemical Research: Used in the development of advanced pesticides and herbicides, where the trifluoromethyl group can enhance biological activity and metabolic stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands or metal-organic frameworks (MOFs) used in asymmetric catalysis.
• Material Science: Employed in the synthesis of fluorinated polymers or liquid crystals with specific optical or electronic properties.
• Chemical Biology Probes: Useful for creating activity-based probes or inhibitors for studying enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3-(2-Methoxyphenyl)-1,1,1-Trifluoro-2-Propanone
CAS No.	870460-18-7
Molecular Formula	C11H9F3O2
Molecular Weight	230.18 g/mol
Synonyms	1,1,1-Trifluoro-3-(2-methoxyphenyl)propan-2-one; 2-Methoxyphenyl Trifluoroacetone; 2'-Methoxy-α,α,α-trifluoroacetophenone; 3-(2-Methoxyphenyl)-1,1,1-trifluoropropan-2-one; 2-Propanone, 1,1,1-trifluoro-3-(2-methoxyphenyl)-; α,α,α-Trifluoro-2'-methoxyacetophenone; 2-Methoxy-α,α,α-trifluoroacetophenone
EINECS	Contact for details

Quality Control

Our 3-(2-Methoxyphenyl)-1,1,1-Trifluoro-2-Propanone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of cGMP and ISO standards for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed when not in use to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.