Description

4-Trifluoromethylpyridine-2-Boronic Acid is a high-value organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via the Suzuki-Miyaura cross-coupling reaction, a cornerstone for constructing complex molecular architectures. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for developing novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules containing trifluoromethylpyridine motifs, which are prevalent in drug discovery for their metabolic stability and lipophilicity.
• Agrochemical Synthesis: Used in creating novel herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and environmental persistence.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid coupling partner with aryl/heteroaryl halides to form biaryl and heterobiaryl structures under palladium catalysis.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands for catalysis and coordination chemistry.
• Material Science Research: A building block for organic electronic materials, such as those used in OLEDs and organic semiconductors, where the electron-withdrawing trifluoromethyl group tunes electronic properties.
• Chemical Biology Probes: Useful for synthesizing labeled compounds or probes for studying biological systems and mechanisms.

Basic Information

Product Name	4-Trifluoromethylpyridine-2-Boronic Acid
CAS No.	870459-90-8
Molecular Formula	C6H5BF3NO2
Molecular Weight	190.92 g/mol
Synonyms	2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-4-(trifluoromethyl)pyridine; 4-(Trifluoromethyl)pyridine-2-boronic acid; (4-(Trifluoromethyl)pyridin-2-yl)boronic acid; 2-Borono-4-trifluoromethylpyridine; 4-Trifluoromethyl-2-pyridineboronic acid; 2-Pyridineboronic acid, 4-(trifluoromethyl)-; Boronic acid, B-[4-(trifluoromethyl)-2-pyridinyl]-
EINECS	Contact for details

Quality Control

Our 4-Trifluoromethylpyridine-2-Boronic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistency. Certificates of Analysis (COA) detailing batch-specific results are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.