Description

1-(4-Ethynylphenyl)Cyclopropane-1-Carbonitrile is a high-purity, advanced pharmaceutical intermediate featuring a unique molecular architecture combining a cyclopropane ring, a nitrile group, and an ethynylphenyl moiety. This compound is of significant value for its role as a versatile building block in modern organic synthesis, particularly in the development of novel active pharmaceutical ingredients (APIs) and functional materials. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for constructing complex molecular frameworks.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, especially for central nervous system (CNS) and oncology targets.
• Agrochemical Synthesis: Used in the creation of novel herbicides, fungicides, and insecticides with specific activity profiles.
• Material Science Research: Serves as a precursor for organic electronic materials, liquid crystals, and polymers due to its rigid, conjugated structure.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological processes, leveraging the reactivity of the alkyne and nitrile groups.
• Cross-Coupling Reactions: The ethynyl group makes it a valuable substrate in Sonogashira and other palladium-catalyzed cross-coupling reactions.
• Academic & Industrial R&D: Employed in exploratory chemistry for method development and the synthesis of novel chemical entities.

Basic Information

Item	Detail
Product Name	1-(4-Ethynylphenyl)Cyclopropane-1-Carbonitrile
CAS No.	869977-87-7
Molecular Formula	C12H9N
Molecular Weight	167.21 g/mol
Synonyms	1-(4-Ethynylphenyl)cyclopropanecarbonitrile; 4-(1-Cyano-1-cyclopropyl)phenylacetylene; 1-Cyclopropyl-1-(4-ethynylphenyl)methanecarbonitrile; 1-(p-Ethynylphenyl)cyclopropanecarbonitrile; 4-(Cyclopropanecarbonitrile)phenylacetylene; (4-Ethynylphenyl)(cyclopropyl)acetonitrile
EINECS	Contact for details

Quality Control

Our production of 1-(4-Ethynylphenyl)Cyclopropane-1-Carbonitrile adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR) against established internal specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The compound may be sensitive to prolonged exposure to air and moisture; therefore, it is recommended to handle under an inert atmosphere for long-term storage and to allow the container to reach ambient temperature before opening.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.