Description

2-(Trifluoromethyl)Phenyl Chloroformate is a specialized organofluorine building block and a reactive chloroformate ester. This compound is valued for its role as a versatile reagent in the synthesis of complex molecules, particularly in pharmaceutical and agrochemical research. It is primarily utilized by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced material sectors for introducing the 2-(trifluoromethyl)phenyloxycarbonyl moiety.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), especially for constructing carbamate or carbonate linkages in drug candidates.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and stability.
• Polymer Chemistry: Serves as a monomer or modifying agent for creating specialty polymers with unique surface properties or degradation profiles.
• Peptide & Protein Research: Acts as a protecting group reagent or a coupling agent in peptide synthesis and bioconjugation strategies.
• Material Science: Employed in the surface functionalization of materials and in the development of liquid crystals or organic electronic components.
• Custom Synthesis & Contract Manufacturing: A critical building block for custom synthesis projects and scale-up processes in fine chemical manufacturing.

Basic Information

Product Name	2-(Trifluoromethyl)Phenyl Chloroformate
CAS No.	869676-40-4
Molecular Formula	C8H4ClF3O2
Molecular Weight	224.56 g/mol
Synonyms	2-(Trifluoromethyl)phenyl carbonochloridate; α,α,α-Trifluoro-o-tolyl Chloroformate; o-(Trifluoromethyl)phenyl Chloroformate; 2-Trifluoromethylphenyl Chloroformate; Chloroformic Acid 2-(Trifluoromethyl)phenyl Ester; (2-Trifluoromethylphenyl) Chloroformate
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Phenyl Chloroformate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, amines, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.