Description

2-(Trifluoromethyl)Pyrrolidine, Hydrochloride is a high-purity, fluorinated pyrrolidine derivative supplied as its hydrochloride salt. This compound is a critical pharmaceutical intermediate and building block for medicinal chemistry, valued for its ability to modulate the physicochemical properties of drug candidates. It is primarily utilized by R&D and production teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in central nervous system (CNS) and metabolic disease research.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies and lead optimization to introduce the trifluoromethyl group, enhancing metabolic stability and lipophilicity.
• Agrochemical Synthesis: Serves as a precursor in the development of advanced herbicides and fungicides.
• Ligand and Catalyst Development: Employed in the creation of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Biology Probes: Used to develop molecular probes for studying biological targets and pathways.
• Peptidomimetics: Incorporated into peptide analogs to improve bioavailability and receptor binding affinity.

Basic Information

Item	Details
Product Name	2-(Trifluoromethyl)Pyrrolidine, Hydrochloride
CAS No.	868623-97-6
Molecular Formula	C5H9ClF3N
Molecular Weight	175.58 g/mol
Synonyms	2-(Trifluoromethyl)pyrrolidine HCl; 2-(Trifluoromethyl)pyrrolidine hydrochloride; Pyrrolidine, 2-(trifluoromethyl)-, hydrochloride (1:1); 2-Trifluoromethylpyrrolidine HCl; 2-(Trifluoromethyl)-1-azacyclopentane hydrochloride
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethyl)Pyrrolidine, Hydrochloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to ensure high chemical purity and identity. Certificates of Analysis (COA) with full traceability are provided for each shipment. We support compliance with ICH guidelines and relevant regulatory frameworks for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under an inert atmosphere or in a desiccator after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.