Description

Ethanone, 2-Chloro-2,2-Difluoro-1-[2-Methoxy-6-[(4-Methylphenyl)Amino]Phenyl]- is a high-purity, specialized organic intermediate featuring a unique difluoroacetophenone core substituted with a methoxy and a tolylamino group. This compound matters as a critical building block in advanced pharmaceutical synthesis, enabling the development of novel active pharmaceutical ingredients (APIs) with targeted properties. It is primarily needed by research and development teams, as well as production chemists, in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting CNS disorders or inflammation.
• Agrochemical Research: Used in the development of next-generation herbicides or fungicides, leveraging its fluorinated structure for enhanced bioactivity and stability.
• Ligand & Catalyst Development: Serves as a sophisticated scaffold for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Advanced Material Synthesis: Employed in the research of organic electronic materials, where its specific substitution pattern can influence charge transport properties.
• Custom Synthesis & Contract Manufacturing: A vital component for CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D projects.
• Fluorine Chemistry Studies: An important reagent for academic and industrial research focused on introducing difluoromethyl and chloro-difluoro motifs into organic molecules.

Basic Information

Item	Details
Product Name	Ethanone, 2-Chloro-2,2-Difluoro-1-[2-Methoxy-6-[(4-Methylphenyl)Amino]Phenyl]-
CAS No.	868395-20-4
Molecular Formula	C16H14ClF2NO2
Molecular Weight	337.74 g/mol
Synonyms	2-Chloro-2,2-difluoro-1-[2-methoxy-6-[(4-methylphenyl)amino]phenyl]ethanone; 1-(2-Chloro-2,2-difluoroacetyl)-2-methoxy-6-(p-toluidino)benzene; 2'-Methoxy-6'-(p-tolylamino)-2-chloro-2,2-difluoroacetophenone; 2-Chloro-2,2-difluoro-1-(2-methoxy-6-(p-tolylamino)phenyl)ethan-1-one; p-Tolyl-[2-(2-chloro-2,2-difluoroacetyl)-3-methoxyphenyl]amine; DFMPA Intermediate; Difluoroacetophenone Derivative
EINECS	Contact for details

Quality Control

Our Ethanone, 2-Chloro-2,2-Difluoro-1-[2-Methoxy-6-[(4-Methylphenyl)Amino]Phenyl]- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients in regulated development pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.