Description

1-(4-Methoxyphenyl)-3-[(2,3,4,5,6-Pentamethylbenzyl)Sulfonyl]-1-Propanone CAS NO 868256-00-2 is a high-purity, synthetic organic compound featuring a unique sulfonyl linker between a methoxyphenyl ketone and a pentamethylbenzyl group. This specialized structure makes it a valuable advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and fine chemical industries for the synthesis of novel active pharmaceutical ingredients (APIs) and other complex molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, particularly in research targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Medicinal Chemistry Research: Used as a core scaffold or precursor for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Fine Chemical Synthesis: Serves as a specialized reagent for constructing complex molecular architectures containing sulfone and aryl ketone functionalities.
• Process Chemistry Development: Employed in route scouting and scale-up optimization for the production of target molecules under Good Manufacturing Practice (GMP) conditions.
• Chemical Biology Probes: Potential use in the development of molecular probes for studying enzyme function and biological pathways.
• Agrochemical Research: May be investigated as an intermediate for developing new crop protection agents with specific modes of action.

Basic Information

Product Name	1-(4-Methoxyphenyl)-3-[(2,3,4,5,6-Pentamethylbenzyl)Sulfonyl]-1-Propanone
CAS No.	868256-00-2
Molecular Formula	C22H26O4S
Molecular Weight	386.51 g/mol
Synonyms	1-Propanone, 1-(4-methoxyphenyl)-3-[(2,3,4,5,6-pentamethylbenzyl)sulfonyl]-; 3-[(2,3,4,5,6-Pentamethylbenzyl)sulfonyl]-1-(4-methoxyphenyl)-1-propanone; 4-Methoxyphenyl 3-(pentamethylbenzylsulfonyl)propyl ketone; Pentamethylbenzylsulfonylpropiophenone derivative; PMB-Sulfonyl Propiophenone; CAS 868256-00-2
EINECS	Contact for details

Quality Control

Our 1-(4-Methoxyphenyl)-3-[(2,3,4,5,6-Pentamethylbenzyl)Sulfonyl]-1-Propanone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity, suitable for research and development applications. All products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.