Description

1-Iodo-3-Methoxy-5-(Trifluoromethyl)Benzene is a high-purity halogenated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring iodine, methoxy, and trifluoromethyl substituents, makes it a versatile intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in cross-coupling reactions and as a precursor to functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for creating molecules with trifluoromethyl groups that enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, where the iodine atom serves as a handle for further functionalization.
• Material Science: Serves as a precursor for liquid crystals, organic semiconductors, and other advanced functional materials due to its electron-withdrawing trifluoromethyl group and potential for palladium-catalyzed couplings.
• Cross-Coupling Reactions: An excellent substrate for Suzuki-Miyaura, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures, which are common motifs in medicinal chemistry.
• Chemical Research & Development: Employed in academic and industrial labs for method development and exploring new synthetic pathways involving halogenated arenes.
• Ligand and Catalyst Preparation: Can be utilized to synthesize specialized phosphine or N-heterocyclic carbene ligands for catalysis.

Basic Information

Product Name	1-Iodo-3-Methoxy-5-(Trifluoromethyl)Benzene
CAS No.	868167-60-6
Molecular Formula	C8H6F3IO
Molecular Weight	302.04 g/mol
Synonyms	3-Iodo-5-Methoxybenzotrifluoride; 5-(Trifluoromethyl)-3-iodoanisole; 3-Methoxy-5-(trifluoromethyl)iodobenzene; 1-Iodo-3-methoxy-5-(trifluoromethyl)benzene; 868167-60-6; 3-Iodo-5-methoxy-α,α,α-trifluorotoluene; 3-Methoxy-α,α,α-trifluoro-5-iodotoluene
EINECS	Contact for details

Quality Control

Our 1-Iodo-3-Methoxy-5-(Trifluoromethyl)Benzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures material consistency and reliability for your critical research and production processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, handling and storage should minimize exposure to direct light.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Typical 98-99%)
Melting Point	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.