Description

4-Carboxy-3-Fluorobenzeneboronicacid,Pinacolester is a high-purity, synthetically valuable boronic ester derivative, serving as a key protected intermediate in modern organic synthesis. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex molecules. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-quality building blocks for drug discovery and development.

Application

• Pharmaceutical Intermediate: A crucial building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl or substituted phenyl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science: Serves as a monomer or precursor in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research & Development: Employed in academic and industrial R&D labs for methodological studies in palladium-catalyzed cross-coupling reactions.
• Suzuki-Miyaura Cross-Coupling: The pinacol ester group offers enhanced stability, making this reagent ideal for coupling reactions to introduce the 4-carboxy-3-fluorophenyl moiety into target molecules.
• Protecting Group Strategy: The carboxylic acid and boronic acid functionalities are protected, allowing for selective deprotection and sequential functionalization in multi-step syntheses.

Basic Information

Product Name	4-Carboxy-3-Fluorobenzeneboronicacid,Pinacolester
CAS No.	867256-77-7
Molecular Formula	C13H16BFO4
Molecular Weight	266.08 g/mol
Synonyms	3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid; 2-(3-Fluoro-4-carboxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-fluorobenzoic acid; 3-Fluoro-4-(pinacolatoboryl)benzoic acid; Benzoic acid, 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Pinacol 3-Fluoro-4-carboxybenzeneboronate
EINECS	Contact for details

Quality Control

Our 4-Carboxy-3-Fluorobenzeneboronicacid,Pinacolester is manufactured under strict quality management protocols to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, containers must be kept tightly sealed and consideration should be given to storage under an inert atmosphere for long-term preservation of quality.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.