Description

1,3,2-Dioxaborolane, 2-Bicyclo[4.2.0]Octa-1,3,5-Trien-3-Yl-4,4,5,5-Tetramethyl- is a specialized organoboron reagent featuring a bicyclic aromatic system tethered to a pinacol boronate ester group. This compound is a critical building block in modern synthetic chemistry, enabling precise carbon-carbon bond formation through cross-coupling reactions. It is primarily utilized by pharmaceutical R&D and advanced materials scientists for constructing complex molecular architectures.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for introducing the bicyclo[4.2.0]octatriene moiety into target molecules for pharmaceutical intermediates.
• Pharmaceutical Research: Synthesis of novel drug candidates and bioactive compounds, particularly in medicinal chemistry programs.
• Agrochemical Development: Building block for creating new active ingredients with complex, fused-ring structures.
• Material Science: Precursor for organic electronic materials, such as novel polymers or small molecules for OLEDs and semiconductors.
• Chemical Biology: Used in the synthesis of probes and tags for studying biological systems.
• Academic & Industrial R&D: Fundamental research tool in synthetic organic chemistry for methodology development and complex molecule synthesis.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-Bicyclo[4.2.0]Octa-1,3,5-Trien-3-Yl-4,4,5,5-Tetramethyl-
CAS No.	866756-09-4
Molecular Formula	C16H21BO2
Molecular Weight	256.15 g/mol
Synonyms	2-(Bicyclo[4.2.0]octa-1,3,5-trien-3-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)bicyclo[4.2.0]octa-1,3,5-triene; Bicyclo[4.2.0]octa-1,3,5-trien-3-ylboronic acid pinacol ester; (Bicyclo[4.2.0]octa-1,3,5-trien-3-yl)pinacolborane; 866756-09-4; Bicyclo[4.2.0]octatriene-3-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our production of this advanced boronic ester adheres to strict quality protocols to ensure batch-to-batch consistency and high reactivity. Every lot is characterized by NMR (1H, 13C, 11B) and HPLC analysis to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) due to its moisture-sensitive nature. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.