Description

(Acetonitrile)[(2-Biphenyl)Di-tert-Butylphosphine]Gold(I) Hexafluoroantimonate is a highly specialized organogold complex catalyst, specifically a cationic gold(I) phosphine complex. This compound matters for its exceptional catalytic activity and selectivity in facilitating complex organic transformations, particularly in the synthesis of fine chemicals and pharmaceutical intermediates. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for cutting-edge synthetic methodology development.

Application

• Homogeneous Gold Catalysis: A premier catalyst for a wide range of reactions including alkyne hydration, hydroamination, and cycloisomerization.
• Pharmaceutical Intermediate Synthesis: Enables key bond-forming steps in the production of complex drug candidates and active pharmaceutical ingredients (APIs).
• Fine Chemical Manufacturing: Used in the synthesis of high-value, structurally complex molecules for specialty applications.
• Methodology Development & Academic Research: A critical reagent for discovering new catalytic pathways and reaction mechanisms in university and industrial R&D labs.
• Ligand-Scope Studies: Serves as a benchmark catalyst for evaluating the performance of bulky phosphine ligands in gold(I) chemistry.

Basic Information

Product Name	(Acetonitrile)[(2-Biphenyl)Di-tert-Butylphosphine]Gold(I) Hexafluoroantimonate
CAS No.	866641-66-9
Molecular Formula	C24H31AuF6NPSb
Molecular Weight	822.21 g/mol
Synonyms	JohnPhos Gold(I) Acetonitrile Complex Hexafluoroantimonate Salt; [(2-Biphenyl)Di-tert-butylphosphine]Gold(I) Acetonitrile Hexafluoroantimonate; JohnPhosAu(NCMe)SbF6; (MeCN)[(2-Biphenylyl)P(t-Bu)2]AuSbF6; Acetonitrile(2-biphenylyl)di-tert-butylphosphinegold(I) hexafluoroantimonate; Gold(I) JohnPhos acetonitrile adduct with SbF6 counterion
EINECS	Contact for details

Quality Control

Every batch of our (Acetonitrile)[(2-Biphenyl)Di-tert-Butylphosphine]Gold(I) Hexafluoroantimonate is synthesized and handled under strict inert atmosphere conditions to ensure maximum catalytic activity and shelf-life. We employ advanced analytical techniques including NMR (1H, 13C, 31P) and HPLC to verify identity, purity, and the absence of deleterious impurities like metallic gold. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a freezer dedicated to moisture- and air-sensitive materials. The compound is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will lead to decomposition and loss of catalytic activity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Gold (Au) Content	23.5 - 24.5 %
Solubility	Soluble in dichloromethane, acetonitrile, THF

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.