Description

n-Cbz-(R)-3-Amino-1-Butanol CAS NO 866395-21-3 is a chiral, N-protected amino alcohol building block of significant importance in asymmetric synthesis. Its primary value lies in serving as a key intermediate for the preparation of more complex, optically active pharmaceutical compounds and fine chemicals. This high-purity intermediate is essential for research and development chemists, process chemists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries who require enantiomerically pure starting materials.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of drugs targeting neurological and cardiovascular diseases.
• Asymmetric Catalyst Ligand Precursor: Used to construct chiral ligands for transition metal catalysts employed in enantioselective hydrogenation, oxidation, and cross-coupling reactions.
• Peptidomimetic Chemistry: Serves as a building block for the synthesis of non-natural amino acids and peptide analogs with enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Employed in the research and production of chiral herbicides, fungicides, and plant growth regulators where specific stereochemistry is critical for activity.
• Material Science: Acts as a monomer or cross-linking agent in the synthesis of specialized polymers with unique optical or mechanical properties.

Basic Information

Product Name	n-Cbz-(R)-3-Amino-1-Butanol
CAS No.	866395-21-3
Molecular Formula	C12H17NO3
Molecular Weight	223.27 g/mol
Synonyms	(R)-3-[(Benzyloxy)carbonyl]amino-1-butanol; (R)-3-(Cbz-Amino)-1-butanol; (R)-N-Carbobenzoxy-3-amino-1-butanol; (R)-3-Amino-1-butanol N-benzyloxycarbonyl derivative; (3R)-3-[[(Benzyloxy)carbonyl]amino]butan-1-ol; Z-(R)-3-Aminobutanol; CBZ-(R)-3-AB; (R)-1-Hydroxy-3-(Cbz-amino)butane
EINECS	Contact for details

Quality Control

Our n-Cbz-(R)-3-Amino-1-Butanol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity (typically >98%), enantiomeric excess (typically >99% ee), and impurity profiles is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.