Description

(E)-2-Cyano-3-(2-Hydroxy-3-Methoxyphenyl)-n-[4-(Trifluoromethyl)Phenyl]-2-Propenamide is a high-purity, synthetic organic compound featuring a distinctive α,β-unsaturated cyanoacrylamide core with methoxy and trifluoromethyl substituents. This molecular architecture makes it a valuable advanced pharmaceutical intermediate and a versatile building block for medicinal chemistry research. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly those targeting kinase inhibition or other enzyme-related pathways.
• Medicinal Chemistry Research: Serves as a critical scaffold for structure-activity relationship (SAR) studies and the development of new chemical entities (NCEs).
• Agrochemical Development: Used in research for creating novel herbicides, fungicides, or insecticides, leveraging the biological activity of the cyanoacrylamide moiety.
• Chemical Biology Probe: Employed in academic and industrial research to study biological processes and identify new therapeutic targets.
• Organic Synthesis Building Block: Utilized in complex multi-step organic syntheses due to its reactive functional groups which allow for further derivatization.

Basic Information

Product Name	(E)-2-Cyano-3-(2-Hydroxy-3-Methoxyphenyl)-n-[4-(Trifluoromethyl)Phenyl]-2-Propenamide
CAS No.	866156-40-3
Molecular Formula	C18H13F3N2O3
Molecular Weight	362.31 g/mol
Synonyms	(E)-2-Cyano-3-(2-hydroxy-3-methoxyphenyl)-N-[4-(trifluoromethyl)phenyl]prop-2-enamide; 2-Propenamide, 2-cyano-3-(2-hydroxy-3-methoxyphenyl)-N-[4-(trifluoromethyl)phenyl]-, (2E)-; (E)-2-Cyano-3-(2-hydroxy-3-methoxyphenyl)-N-(4-(trifluoromethyl)phenyl)acrylamide; (E)-3-(2-Hydroxy-3-methoxyphenyl)-2-cyano-N-(4-(trifluoromethyl)phenyl)acrylamide; α-Cyano-β-(2-hydroxy-3-methoxyphenyl)-N-[4-(trifluoromethyl)phenyl]-(E)-acrylamide
EINECS	Contact for details

Quality Control

Our (E)-2-Cyano-3-(2-Hydroxy-3-Methoxyphenyl)-n-[4-(Trifluoromethyl)Phenyl]-2-Propenamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment supports compliance with cGMP standards for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). For long-term storage, consider packaging under an inert gas such as nitrogen or argon.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.