Description

2-(4-Chloro-2-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is a high-purity boronic ester derivative, a crucial intermediate in modern synthetic organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds under mild conditions. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-quality building blocks for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl or heterobiaryl motifs.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides requiring specific chlorinated aromatic structures.
• Material Science Research: Serves as a monomer or precursor in the development of organic electronic materials, such as polymers for OLEDs or organic photovoltaics.
• Ligand and Catalyst Development: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology Probes: Useful for creating tagged molecules or probes for studying biological processes and target engagement.
• Custom Synthesis & Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences industry.

Basic Information

Product Name	2-(4-Chloro-2-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
CAS No.	866141-76-6
Molecular Formula	C13H18BClO3
Molecular Weight	268.54 g/mol
Synonyms	4-Chloro-2-methoxyphenylboronic acid pinacol ester; (4-Chloro-2-methoxyphenyl)boronic acid pinacol ester; 2-Methoxy-4-chlorophenylboronic acid pinacol ester; Pinacol (4-chloro-2-methoxyphenyl)boronate; 4-Chloro-2-methoxybenzeneboronic acid pinacol ester; B-(4-Chloro-2-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-(4-Chloro-2-Methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive coupling reactions. Each lot undergoes rigorous analytical testing, including NMR (¹H, ¹³C, ¹¹B), HPLC, and GC analysis, to confirm identity and quantify purity and potential impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) for long-term stability, especially after opening the original container. Ideal storage temperature is between 2°C and 8°C (refrigerated).

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.