Description

1-(3,5-Difluorophenyl)Propan-2-One is a high-purity fluorinated aromatic ketone building block of significant importance in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms on the phenyl ring, which can dramatically alter the electronic properties, metabolic stability, and binding affinity of final target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, where it serves as a key intermediate for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of modern pesticides and herbicides, where the difluorophenyl moiety contributes to improved efficacy and environmental profile.
• Material Science Research: Serves as a building block for creating novel fluorinated polymers, liquid crystals, and organic electronic materials with enhanced performance characteristics.
• Chemical Biology & Proteomics: Employed as a versatile scaffold for designing molecular probes, enzyme inhibitors, and tags used in biochemical research and drug discovery.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-(3,5-Difluorophenyl)Propan-2-One
CAS No.	865774-77-2
Molecular Formula	C9H8F2O
Molecular Weight	170.16 g/mol
Synonyms	3',5'-Difluoropropiophenone; 1-Propanone, 1-(3,5-difluorophenyl)-2-; 2-Propanone, 1-(3,5-difluorophenyl)-; 3,5-Difluorophenylacetone; (3,5-Difluorophenyl)acetone; 1-Acetyl-2-(3,5-difluorophenyl)ethane
EINECS	Contact for details

Quality Control

Every batch of 1-(3,5-Difluorophenyl)Propan-2-One is produced and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. A comprehensive Certificate of Analysis (COA), detailing purity, identity, and impurity profiles as determined by techniques like HPLC, GC, and NMR, is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.