Description

(E)-1-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)allyl)-4-(trifluoromethyl)piperidine is a high-value, advanced pharmaceutical intermediate featuring a strategically positioned boronic ester functional group. This compound matters as a critical building block in modern synthetic chemistry, enabling efficient cross-coupling reactions for the construction of complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a key boronic ester reagent for the palladium-catalyzed formation of carbon-carbon bonds, a cornerstone of medicinal chemistry.
• Pharmaceutical Intermediate: Used in the research and development of new drug candidates, particularly those targeting central nervous system (CNS) disorders, due to the presence of the trifluoromethylpiperidine moiety.
• Agrochemical Synthesis: Employed in the creation of novel pesticides and herbicides where the introduction of specific fluorinated and heterocyclic structures is required for bioactivity.
• Material Science Research: Acts as a precursor for the synthesis of organic electronic materials and liquid crystals, leveraging its conjugated system and functional handles.
• Process Chemistry & Scale-Up: Provides a stable and handleable source of the vinylboronate species for kilogram-scale manufacturing under GMP conditions.

Basic Information

Product Name	(E)-1-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)allyl)-4-(trifluoromethyl)piperidine
CAS No.	865652-21-7
Molecular Formula	C15H25BF3NO2
Molecular Weight	319.18 g/mol
Synonyms	4-(Trifluoromethyl)-1-[(1E)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-propen-1-yl]piperidine; 1-[(1E)-3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-propen-1-yl]-4-(trifluoromethyl)piperidine; (E)-4,4,5,5-Tetramethyl-2-(3-(4-(trifluoromethyl)piperidin-1-yl)prop-1-en-1-yl)-1,3,2-dioxaborolane; 865652-21-7; Pinacol (E)-1-(3-(4-(trifluoromethyl)piperidin-1-yl)allyl)boronate
EINECS	Contact for details

Quality Control

Our (E)-1-(3-(4,4,5,5-Tetramethyl-1,3,2-Dioxaborolan-2-yl)allyl)-4-(trifluoromethyl)piperidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided and can be tailored to support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term stability, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C (refrigerated). Allow the container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.