Description

3-Bromomethyl-3-Fluorooxetane (CAS NO 865451-86-1) is a highly versatile and reactive fluorinated oxetane building block, prized for its ability to introduce both fluorine and a bromomethyl functional handle into complex molecular architectures. This compound is critical for the synthesis of advanced materials and active pharmaceutical ingredients (APIs) where specific fluorine substitution patterns are required to modulate properties like metabolic stability, lipophilicity, and bioavailability. It is primarily sought after by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty polymer industries.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel fluorinated drug candidates, particularly in antiviral, anticancer, and CNS-targeted therapies.
• Agrochemical Synthesis: Used in the development of next-generation fluorinated pesticides and herbicides to enhance their environmental stability and efficacy.
• Polymer & Material Science: Serves as a monomer or cross-linking agent for creating fluorinated polymers with unique surface properties, chemical resistance, and low dielectric constants.
• Liquid Crystal & OLED Materials: Incorporated into the core structure of fluorinated liquid crystals and organic light-emitting diode (OLED) materials to improve performance and stability.
• Proteolysis Targeting Chimeras (PROTACs): Utilized as a linker component in the design of bifunctional PROTAC molecules for targeted protein degradation.
• Fluorine-18 Radiochemistry: Potential precursor for the synthesis of positron emission tomography (PET) imaging agents, leveraging its reactive bromomethyl group for radiolabeling.

Basic Information

Product Name	3-Bromomethyl-3-Fluorooxetane
CAS No.	865451-86-1
Molecular Formula	C4H6BrFO
Molecular Weight	168.99 g/mol
Synonyms	3-(Bromomethyl)-3-fluorooxetane; 3-Fluoro-3-(bromomethyl)oxetane; 3-Bromofluoromethyloxetane; Oxetane, 3-(bromomethyl)-3-fluoro-; 3-Fluorooxetane-3-methyl bromide; 865451-86-1; 3-Bromo-3-fluoromethyloxetane; 3-Fluoro-3-bromomethyloxetane
EINECS	Contact for details

Quality Control

Our 3-Bromomethyl-3-Fluorooxetane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and Karl Fischer titration, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C. Due to its hygroscopic and moisture-sensitive nature, containers should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 1.0%; Total impurities ≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.