Description

1-(4-Bromo-5-Fluoro-2-Hydroxyphenyl)Ethanone is a high-purity, halogenated aromatic ketone building block of significant interest in advanced organic synthesis. Its unique molecular structure, featuring bromine and fluorine substituents adjacent to a phenolic hydroxyl group, makes it a versatile intermediate for constructing complex pharmacophores. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical sectors. It serves as a critical precursor in the synthesis of novel active ingredients, where its halogen atoms provide key sites for further functionalization and influence the biological activity of the final molecules.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel drug candidates, particularly in developing kinase inhibitors, anti-inflammatory agents, and central nervous system (CNS) active compounds.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and pesticides, where the bromo-fluoro substitution pattern can enhance bioactivity and environmental selectivity.
• Material Science Research: Serves as a monomer or precursor for synthesizing specialty polymers, liquid crystals, and organic electronic materials that require halogenated aromatic units.
• Chemical Biology & Proteomics: Employed as a scaffold for developing molecular probes, activity-based protein profiling (ABPP) reagents, and photoaffinity labels due to its reactive ketone and hydroxyl groups.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for use in client-specific, multi-step synthetic routes for complex target molecules.

Basic Information

Product Name	1-(4-Bromo-5-Fluoro-2-Hydroxyphenyl)Ethanone
CAS No.	865449-63-4
Molecular Formula	C8H6BrFO2
Molecular Weight	233.04 g/mol
Synonyms	4'-Bromo-5'-fluoro-2'-hydroxyacetophenone; 1-(4-Bromo-5-fluoro-2-hydroxyphenyl)ethan-1-one; 2-Acetyl-5-bromo-4-fluorophenol; 4-Bromo-5-fluoro-2-hydroxyacetophenone; 5-Bromo-4-fluoro-2-hydroxyacetophenone; 2-Hydroxy-4-bromo-5-fluoroacetophenone; Ethanone, 1-(4-bromo-5-fluoro-2-hydroxyphenyl)-
EINECS	Contact for details

Quality Control

Our 1-(4-Bromo-5-Fluoro-2-Hydroxyphenyl)Ethanone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with every shipment, documenting all critical quality attributes. Our commitment to cGMP (current Good Manufacturing Practice) principles ensures the material is suitable for demanding research and pre-clinical development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect from moisture. Store away from incompatible materials such as strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.