Description

3-Ethyl-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole is a high-value, advanced pharmaceutical intermediate and building block for medicinal chemistry. This compound is critical for modern drug discovery, particularly in the development of targeted small-molecule therapies. It is primarily utilized by research institutions and pharmaceutical companies engaged in the synthesis of kinase inhibitors and other biologically active molecules.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially kinase inhibitors for oncology and inflammatory diseases.
• Suzuki-Miyaura Cross-Coupling Reactions: The boronic ester pinacol group makes it an essential reagent for forming carbon-carbon bonds in complex molecule assembly.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization programs to develop new therapeutic agents.
• Bioconjugation and Probe Development: Serves as a precursor for creating labeled compounds and molecular probes used in biochemical assays and diagnostic research.
• Contract Research and Manufacturing (CRO/CMO): Supplied to organizations specializing in custom synthesis and scale-up of active pharmaceutical ingredients (APIs).
• Academic Research: Employed in university and institutional labs for methodological development in organic and heterocyclic chemistry.

Basic Information

Product Name	3-Ethyl-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole
CAS No.	864774-69-6
Molecular Formula	C15H21BN2O2
Molecular Weight	272.15 g/mol
Synonyms	3-Ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 1H-Indazole, 3-ethyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 3-Ethyl-5-(pinacolboron)-1H-indazole; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-3-ethyl-1H-indazole; 864774-69-6; 3-Ethyl-5-(pinacolatoboryl)-1H-indazole; 3-Ethyl-1H-indazole-5-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 3-Ethyl-5-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to cGMP guidelines where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and during weighing to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.