Description

1-(5-Bromo-2,4-Difluoro-Phenyl)-Ethanone is a high-purity, multi-functional aromatic ketone building block essential for advanced organic synthesis. Its unique halogenated difluorophenyl structure makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting new therapeutic agents.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides, leveraging its halogenated aromatic core.
• Material Science Research: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination, facilitated by the reactive bromine atom.
• Functional Group Transformation: The acetyl (ethanone) group provides a handle for further chemical modifications, including reductions, oxidations, and nucleophilic additions.
• Fluorine Chemistry: The difluoro substitution pattern is valuable for modulating lipophilicity, metabolic stability, and bioavailability in medicinal chemistry.

Basic Information

Product Name	1-(5-Bromo-2,4-Difluoro-Phenyl)-Ethanone
CAS No.	864773-64-8
Molecular Formula	C8H5BrF2O
Molecular Weight	235.03 g/mol
Synonyms	5'-Bromo-2',4'-difluoroacetophenone; 5-Bromo-2,4-difluoroacetophenone; 1-Acetyl-5-bromo-2,4-difluorobenzene; 2,4-Difluoro-5-bromoacetophenone; (5-Bromo-2,4-difluorophenyl)ethan-1-one; Ethanone, 1-(5-bromo-2,4-difluorophenyl)-; Acetophenone, 5'-bromo-2',4'-difluoro-
EINECS	Contact for details

Quality Control

Our 1-(5-Bromo-2,4-Difluoro-Phenyl)-Ethanone is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our commitment to cGMP principles and relevant ICH guidelines ensures a reliable supply for demanding research and scale-up applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.