Description

1,3,2-Dioxaborolane, 2-[2-[(3-Fluorophenyl)Methoxy]Phenyl]-4,4,5,5-Tetramethyl- is a high-value, organoboron building block featuring a pinacol boronate ester group and a fluorinated aromatic ether moiety. This compound is critical for enabling advanced cross-coupling reactions, particularly Suzuki-Miyaura couplings, which are foundational to modern pharmaceutical and agrochemical synthesis. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for constructing complex molecular architectures with precision.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing biaryl or heterobiaryl structures common in kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides where the introduction of a fluorinated phenyl group can enhance biological activity and metabolic stability.
• Material Science Research: Serves as a monomer or cross-linking agent in the development of organic electronic materials, such as polymers for OLEDs or OFETs, due to its boronate functionality.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and tags for bio-conjugation and imaging applications, leveraging the selective reactivity of the boronate ester.
• Catalyst Ligand Synthesis: Acts as a building block for synthesizing sophisticated ligand systems used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-directed synthesis projects requiring specific, high-purity boronic ester derivatives.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[2-[(3-Fluorophenyl)Methoxy]Phenyl]-4,4,5,5-Tetramethyl-
CAS No.	864772-77-0
Molecular Formula	C19H22BFO3
Molecular Weight	328.19 g/mol
Synonyms	2-(2-((3-Fluorobenzyl)oxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; [2-[(3-Fluorophenyl)methoxy]phenyl]boronic acid pinacol ester; (2-((3-Fluorobenzyl)oxy)phenyl)boronic acid pinacol ester; 3-Fluorobenzyl 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl ether; PINACOL (2-((3-FLUOROBENZYL)OXY)PHENYL)BORONATE
EINECS	Contact for details

Quality Control

Every batch of our 1,3,2-Dioxaborolane derivative is produced and tested under strict quality management protocols to ensure consistency and reliability for your critical synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to support cGMP-compliant manufacturing for pharmaceutical customers, and we can accommodate custom purity specifications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from strong oxidizers.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0% (Area %)
Purity (NMR)	Conforms
Water Content (KF)	≤0.5% w/w
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.