Description

1,3,2-Dioxaborolane, 2-[3-[(3-Fluorophenyl)Methoxy]Phenyl]-4,4,5,5-Tetramethyl- is a high-value, organoboron building block featuring a protected boronic ester group and a fluorinated aromatic ether linkage. This compound is essential for facilitating complex cross-coupling reactions, particularly in the synthesis of advanced pharmaceutical intermediates and functional materials. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and materials science sectors who require precise and reliable synthetic tools.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for constructing biaryl and heterobiaryl structures in drug discovery and development.
• Pharmaceutical Intermediate Synthesis: Used in the synthesis of active pharmaceutical ingredients (APIs), especially those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Serves as a building block for novel herbicides, fungicides, and insecticides with enhanced activity.
• Liquid Crystal & OLED Material Development: Incorporated into the backbone of organic electronic materials to tune electronic properties and stability.
• Polymer Chemistry: Enables the synthesis of specialty polymers and functionalized materials via controlled polymerization techniques.
• Chemical Biology & Probe Development: Utilized for creating molecular probes and bioconjugates for diagnostic and research applications.

Basic Information

Product Name	1,3,2-Dioxaborolane, 2-[3-[(3-Fluorophenyl)Methoxy]Phenyl]-4,4,5,5-Tetramethyl-
CAS No.	864771-48-2
Molecular Formula	C19H22BFO3
Molecular Weight	328.19 g/mol
Synonyms	2-(3-((3-Fluorobenzyl)oxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; [3-(3-Fluorobenzyloxy)phenyl]boronic acid pinacol ester; 3-(3-Fluorobenzyloxy)phenylboronic acid pinacol ester; (3-((3-Fluorobenzyl)oxy)phenyl)boronic acid pinacol ester; 3-Fluoro-3'-methoxy-[1,1'-biphenyl]-3-ylboronic acid pinacol ester (related); PINACOL (3-(3-FLUOROBENZYLOXY)PHENYL)BORONATE; B-[3-[(3-Fluorophenyl)methoxy]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our production of this advanced boronic ester adheres to strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot is characterized using advanced analytical techniques including NMR (¹H, ¹³C, ¹⁹F, ¹¹B), HPLC, and GC to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged manipulations to maintain stability and purity. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.