Description

n-(2-Cyano-Ethyl)-n-Pyridin-3-Ylmethyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzamide is a high-value, multi-functional organic building block featuring a boronic ester pinacol group and a cyanoethyl-protected amine. This compound matters as a critical intermediate for constructing complex molecules via Suzuki-Miyaura cross-coupling reactions, enabling the synthesis of novel active pharmaceutical ingredients (APIs) and advanced materials. It is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require reliable, high-purity intermediates for efficient synthesis.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Research: Used in the development of new pesticides and herbicides with complex aromatic structures.
• Material Science: Precursor for creating functional polymers, liquid crystals, and organic electronic materials.
• Suzuki-Miyaura Cross-Coupling: The pinacol boronate ester moiety makes it an ideal partner for palladium-catalyzed coupling with aryl halides.
• Chemical Biology Probes: Serves as a versatile handle for labeling and modifying biomolecules in probe development.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for client-specific synthesis projects requiring bespoke boronic acid derivatives.

Basic Information

Product Name	n-(2-Cyano-Ethyl)-n-Pyridin-3-Ylmethyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzamide
CAS No.	864759-44-4
Molecular Formula	C23H28BN3O3
Molecular Weight	405.30 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-[2-(cyanoethyl)(pyridin-3-ylmethyl)amino]benzamide; N-(2-Cyanoethyl)-N-(pyridin-3-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 864759-44-4; Benzamide, N-(2-cyanoethyl)-N-(3-pyridinylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Boronic acid, B-[4-[[[2-cyanoethyl)(3-pyridinylmethyl)amino]carbonyl]phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our n-(2-Cyano-Ethyl)-n-Pyridin-3-Ylmethyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzamide is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment supports compliance with cGMP and ISO standards for pharmaceutical and fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); keep the container tightly sealed under an inert atmosphere (nitrogen or argon) when not in use to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.