Description

n-Ethyl-n-Pyridin-4-Ylmethyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzamide is a high-value, organoboron building block critical for modern synthetic chemistry, particularly in pharmaceutical research and development. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a pivotal method for constructing complex carbon-carbon bonds. This compound is essential for medicinal chemists and process R&D teams in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable, high-purity intermediates for drug discovery and fine chemical synthesis.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl structures.
• Suzuki-Miyaura Cross-Coupling Reagent: The boronic ester pinacol group acts as a stable, reactive handle for palladium-catalyzed coupling with aryl halides, enabling efficient library synthesis.
• Medicinal Chemistry Research: Used extensively in hit-to-lead and lead optimization campaigns to explore structure-activity relationships (SAR) and develop novel therapeutic agents.
• Agrochemical Synthesis: Employed in the development of new herbicides, fungicides, and insecticides that require complex aromatic architectures.
• Ligand and Catalyst Development: The pyridine moiety can be utilized to create novel ligands for catalysis or functional materials.
• Material Science: Potential use in the synthesis of organic electronic materials, such as those for OLEDs or organic photovoltaics, where precise molecular control is required.

Basic Information

Item	Details
Product Name	n-Ethyl-n-Pyridin-4-Ylmethyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzamide
CAS No.	864759-43-3
Molecular Formula	C22H29BN2O3
Molecular Weight	380.29 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-ethyl-N-(pyridin-4-ylmethyl)benzamide; N-Ethyl-N-((pyridin-4-yl)methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; 864759-43-3; Benzamide, N-ethyl-N-(4-pyridinylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Boronic acid, B-[4-[(ethyl)[(4-pyridinylmethyl)amino]carbonyl]phenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester
EINECS	Contact for details

Quality Control

Our n-Ethyl-n-Pyridin-4-Ylmethyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzamide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. Each lot undergoes comprehensive analytical characterization, including HPLC, NMR (1H, 13C, 11B), and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support cGMP compliance for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage or after opening to prevent hydrolysis of the boronic ester functionality. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.