Description

n-Methyl-n-(2-Pyridin-2-Yl-Ethyl)-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzamide is a high-value, advanced pharmaceutical intermediate featuring a pinacol boronate ester functional group. This compound is critical for enabling key carbon-carbon bond-forming reactions, specifically Suzuki-Miyaura cross-couplings, in complex molecule synthesis. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of novel active pharmaceutical ingredients (APIs), agrochemicals, and functional materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables the efficient and selective formation of biaryl and other carbon-carbon bonds in medicinal chemistry and process development.
• Agrochemical Research: Used in the discovery and development of new pesticides and herbicides that require specific aryl-boronate motifs.
• Material Science: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Chemical Biology & Proteomics: Employed as a tool compound or linker in the development of chemical probes and bioconjugation strategies.
• Contract Research & Development (CRO/CDMO): Supplied to service organizations for custom synthesis and scale-up projects for global clients.

Basic Information

Product Name	n-Methyl-n-(2-Pyridin-2-Yl-Ethyl)-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzamide
CAS No.	864759-42-2
Molecular Formula	C22H29BN2O3
Molecular Weight	380.29 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-N-methyl-N-[2-(2-pyridinyl)ethyl]benzamide; N-Methyl-N-(2-pyridin-2-ylethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide; Benzamide, N-methyl-N-[2-(2-pyridinyl)ethyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; Boronic acid, B-[4-[[[2-(2-pyridinyl)ethyl]methylamino]carbonyl]phenyl]-, 4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; 864759-42-2; Pinacol ester of 4-((Methyl(2-(pyridin-2-yl)ethyl)amino)carbonyl)phenylboronic acid
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is characterized and tested using advanced analytical techniques including HPLC, NMR, and LC-MS to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet the specific requirements of cGMP, ICH Q7, or other regulatory frameworks for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.