Description

4,4,5,5-Tetramethyl-2-(4-Methylsulfanylmethoxy-Phenyl)-[1,3,2]Dioxaborolane is a high-purity, advanced pharmaceutical intermediate and key building block in organic synthesis. This compound matters for its critical role in facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. Researchers and process chemists in pharmaceutical R&D and fine chemical manufacturing need this boronic ester for the efficient and scalable synthesis of active pharmaceutical ingredients (APIs) and novel molecular entities.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of complex drug molecules, particularly those containing biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a stable, air-tolerant boronic ester partner for palladium-catalyzed carbon-carbon bond formation.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require specific aryl-aryl linkages.
• Material Science & OLED Development: Acts as a building block for creating organic semiconductors, light-emitting materials, and advanced polymers.
• Ligand & Catalyst Synthesis: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis.
• Chemical Biology & Probe Development: Utilized for labeling and modifying biomolecules or creating fluorescent probes for diagnostic applications.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(4-Methylsulfanylmethoxy-Phenyl)-[1,3,2]Dioxaborolane
CAS No.	864754-50-7
Molecular Formula	C14H21BO3S
Molecular Weight	280.19 g/mol
Synonyms	2-(4-(Methylthio)methoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(Methylthiomethoxy)phenylboronic acid pinacol ester; (4-((Methylthio)methoxy)phenyl)boronic acid pinacol ester; 4,4,5,5-Tetramethyl-2-[4-[(methylsulfanyl)methoxy]phenyl]-1,3,2-dioxaborolane; PINACOL (4-(METHYLTHIOMETHOXY)PHENYL)BORONATE; 4-(Methylsulfanylmethoxy)benzeneboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 4,4,5,5-Tetramethyl-2-(4-Methylsulfanylmethoxy-Phenyl)-[1,3,2]Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥98.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.