Description

2-[4-(2,2-Difluoro-Ethoxy)-Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is a high-purity, advanced pharmaceutical intermediate belonging to the class of pinacol boronic esters. This compound is a critical building block in modern synthetic organic chemistry, particularly for Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl structures. It is primarily utilized by R&D scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for the development of novel active ingredients and functional molecules. Its specific difluoroethoxy-phenyl substitution pattern makes it valuable for creating compounds with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs) for various therapeutic areas, including oncology and central nervous system (CNS) disorders.
• Suzuki-Miyaura Cross-Coupling Reactions: Serves as a versatile boronic ester reagent for palladium-catalyzed carbon-carbon bond formation, essential for creating complex biaryl and heterobiaryl scaffolds.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the difluoroethoxy group's influence on biological activity.
• Material Science: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs and semiconductors, where precise molecular architecture is required.
• Chemical Biology & Probe Development: Acts as a building block for creating molecular probes and tools used in biochemical and diagnostic research.
• Process Chemistry & Scale-Up: Supplied in development and commercial quantities to support route scouting, optimization, and GMP manufacturing campaigns.

Basic Information

Product Name	2-[4-(2,2-Difluoro-Ethoxy)-Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane
CAS No.	864754-48-3
Molecular Formula	C16H23BF2O3
Molecular Weight	312.16 g/mol
Synonyms	4,4,5,5-Tetramethyl-2-[4-(2,2-difluoroethoxy)phenyl]-1,3,2-dioxaborolane; [4-(2,2-Difluoroethoxy)phenyl]boronic acid pinacol ester; 2-(4-(2,2-Difluoroethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Pinacol [4-(2,2-Difluoroethoxy)phenyl]boronate; 4-(2,2-Difluoroethoxy)benzeneboronic acid pinacol ester; 864754-48-3; Boronic acid, B-[4-(2,2-difluoroethoxy)phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 2-[4-(2,2-Difluoro-Ethoxy)-Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring reliable consistency and traceability for your development and manufacturing needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5% w/w
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.