Description

2-[4-(2-Fluoro-Ethoxy)-Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is a high-purity, advanced boronic ester building block essential for modern synthetic chemistry. This compound matters because it serves as a critical intermediate in the synthesis of complex molecules, particularly through cross-coupling reactions like the Suzuki-Miyaura reaction. Pharmaceutical R&D and agrochemical manufacturers need it for the efficient construction of novel active ingredients and functional materials, where its fluoroethoxy moiety offers unique electronic and steric properties.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the research and development of novel herbicides and fungicides, leveraging its structural motif for enhanced bioactivity.
• Material Science Research: Employed in the creation of organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is required.
• Suzuki-Miyaura Cross-Coupling Reactions: Acts as a versatile boronate ester partner for forming carbon-carbon bonds with aryl halides, a cornerstone of modern organic synthesis.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: The fluoroethoxy group makes it valuable for investigating the effects of fluorine substitution on pharmacokinetics and material properties.

Basic Information

Product Name	2-[4-(2-Fluoro-Ethoxy)-Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane
CAS No.	864754-47-2
Molecular Formula	C₁₆H₂₄BFO₃
Molecular Weight	294.17 g/mol
Synonyms	4-(2-Fluoroethoxy)phenylboronic acid pinacol ester; 2-(4-(2-Fluoroethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; (4-(2-Fluoroethoxy)phenyl)boronic acid pinacol ester; 864754-47-2; 4-(2-Fluoroethoxy)benzeneboronic acid pinacol ester; 1,3,2-Dioxaborolane, 2-[4-(2-fluoroethoxy)phenyl]-4,4,5,5-tetramethyl-; PINACOL 4-(2-FLUOROETHOXY)BENZENEBORONATE
EINECS	Contact for details

Quality Control

Our 2-[4-(2-Fluoro-Ethoxy)-Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and batch-to-batch consistency suitable for demanding R&D and scale-up applications. Certificates of Analysis (COA) with full traceability are provided and can be tailored to meet specific customer or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.