Description

4,4,5,5-Tetramethyl-2-(3-Methylsulfanylmethoxy-Phenyl)-[1,3,2]Dioxaborolane is a high-purity, advanced pharmaceutical intermediate and versatile synthetic building block. This compound is valued for its role in facilitating efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of modern organic synthesis. It is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries developing novel active ingredients and functional molecules. Our supply ensures consistent quality and reliability for critical R&D and scale-up processes.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of complex drug candidates, particularly in oncology and central nervous system (CNS) therapeutic areas.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides requiring specific aryl-boronate functionalities.
• Material Science Research: Serves as a precursor for creating organic electronic materials, such as those used in OLEDs and organic photovoltaics.
• Suzuki-Miyaura Cross-Coupling: A critical reagent for palladium-catalyzed coupling reactions to form biaryl structures, a common motif in many advanced chemicals.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and activity-based protein profiling (ABPP) agents.
• Ligand and Catalyst Development: Useful for synthesizing novel bidentate ligands and organometallic catalysts.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-(3-Methylsulfanylmethoxy-Phenyl)-[1,3,2]Dioxaborolane
CAS No.	864754-44-9
Molecular Formula	C14H21BO3S
Molecular Weight	280.19 g/mol
Synonyms	(3-((Methylthio)methoxy)phenyl)boronic acid pinacol ester; 2-(3-((Methylsulfanyl)methoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 3-((Methylthio)methoxy)benzeneboronic acid pinacol ester; Pinacol [3-((methylthio)methoxy)phenyl]boronate; B-[3-[(Methylthio)methoxy]phenyl]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 864754-44-9; Boronic acid, B-[3-[(methylthio)methoxy]phenyl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Every batch of 4,4,5,5-Tetramethyl-2-(3-Methylsulfanylmethoxy-Phenyl)-[1,3,2]Dioxaborolane is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for sensitive coupling reactions and pharmaceutical applications. A detailed Certificate of Analysis (COA) including HPLC purity, NMR confirmation, and residual solvent analysis is supplied with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (argon or nitrogen) after opening to prevent degradation. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.