Description

1-(2,2-Dimethoxy-Ethyl)-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Pyrazole is a high-value, multi-functional boronic ester derivative that serves as a critical building block in modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone technology for constructing complex molecules. This advanced intermediate is essential for researchers and process chemists in the pharmaceutical, agrochemical, and materials science industries who are developing new active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in heterocyclic drug discovery programs targeting CNS disorders, oncology, and inflammation.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides that require specific pyrazole-boronate motifs.
• Material Science Precursor: Employed in the creation of organic electronic materials, such as organic light-emitting diodes (OLEDs) and semiconductors, where its structure allows for fine-tuning of electronic properties.
• Cross-Coupling Reactions: A dedicated reagent for Suzuki-Miyaura cross-coupling, facilitating the efficient and selective introduction of the pyrazole moiety into complex molecular architectures.
• Chemical Biology Probes: Serves as a versatile handle for bioconjugation and the development of chemical probes for proteomics and diagnostic assay development.
• Ligand Synthesis: Intermediate for the preparation of specialized ligands used in catalysis and metal-organic frameworks (MOFs).

Basic Information

Item	Details
Product Name	1-(2,2-Dimethoxy-Ethyl)-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	864754-40-5
Molecular Formula	C₁₃H₂₅BN₂O₄
Molecular Weight	284.16 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2-dimethoxyethyl)-1H-pyrazole; 1-(2,2-Dimethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1H-Pyrazole, 1-(2,2-dimethoxyethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 864754-40-5; 1-(2,2-Dimethoxyethyl)-4-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; Pyrazole boronic ester pinacol derivative
EINECS	Contact for details

Quality Control

Our 1-(2,2-Dimethoxy-Ethyl)-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance in sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and compliance with your research or production specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. Due to its hygroscopic (moisture-sensitive) nature, it is recommended to store the product under an inert atmosphere (e.g., nitrogen or argon) and handle it in a dry environment to prevent hydrolysis of the boronic ester functionality. Recommended long-term storage temperature is 2-8°C.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.