Description

4-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzenesulfonyl]-Thiomorpholine is a high-value, multi-functional chemical building block that combines a sulfonamide linker with a protected boronic ester moiety. This compound matters for its critical role as a key intermediate in modern synthetic chemistry, enabling the construction of complex molecules through versatile cross-coupling reactions. It is primarily needed by pharmaceutical R&D teams and fine chemical manufacturers for developing new active pharmaceutical ingredients (APIs), agrochemicals, and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing novel drug candidates, particularly in oncology and CNS therapeutic areas.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the boronic ester group for selective bond formation.
• Material Science Research: Serves as a building block for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed in the synthesis of activity-based probes and molecular tools for studying enzyme function and protein interactions.
• Library Synthesis for Drug Discovery: Facilitates the rapid generation of diverse compound libraries in medicinal chemistry programs through parallel synthesis.
• Catalyst and Ligand Development: Acts as a precursor for novel ligands and organometallic catalysts used in asymmetric synthesis.

Basic Information

Product Name	4-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzenesulfonyl]-Thiomorpholine
CAS No.	864754-37-0
Molecular Formula	C16H24BNO4S2
Molecular Weight	369.31 g/mol
Synonyms	3-((Thiomorpholinosulfonyl)phenyl)boronic acid pinacol ester; 3-(Thiomorpholine-4-sulfonyl)phenylboronic acid pinacol ester; 4-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonyl]thiomorpholine; 3-(Thiomorpholinosulfonyl)phenylboronic Acid Pinacol Ester; 864754-37-0; 4-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenylsulfonyl]thiomorpholine; Benzenesulfonic acid, 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-, 4-thiomorpholide
EINECS	Contact for details

Quality Control

Our production of 4-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzenesulfonyl]-Thiomorpholine adheres to stringent quality management systems to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.