Description

1-(2,2-Dimethoxy-Ethyl)-3,5-Dimethyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Pyrazole is a high-purity, advanced pharmaceutical intermediate and versatile synthetic building block. Its core value lies in its unique structure, which incorporates a protected boronic ester functional group, making it a critical reagent for modern cross-coupling reactions like the Suzuki-Miyaura reaction. This compound is essential for research chemists and process development teams in the pharmaceutical, agrochemical, and materials science industries who require reliable, high-quality building blocks for constructing complex molecules.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for drugs targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Suzuki-Miyaura Cross-Coupling Reagent: The pinacol boronate ester group enables efficient carbon-carbon bond formation, crucial for creating biaryl and heterobiaryl structures in medicinal chemistry.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require complex pyrazole-based architectures.
• Organic Light-Emitting Diode (OLED) Materials: Serves as a building block for electron-transport or host materials in the development of advanced display and lighting technologies.
• Ligand Synthesis for Catalysis: Useful for constructing sophisticated pyrazole-containing ligands used in homogeneous catalysis.
• Chemical Biology & Proteolysis Targeting Chimeras (PROTACs): Employed as a linker or functional component in the design of novel chemical probes and targeted protein degraders.

Basic Information

Product Name	1-(2,2-Dimethoxy-Ethyl)-3,5-Dimethyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Pyrazole
CAS No.	864754-33-6
Molecular Formula	C15H27BN2O4
Molecular Weight	310.20 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2,2-dimethoxyethyl)-3,5-dimethyl-1H-pyrazole; 1-(2,2-Dimethoxyethyl)-3,5-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 3,5-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-ethanol, 2,2-dimethyl acetal; Pyrazole boronic ester pinacol; 864754-33-6; Boric acid, B-[1-(2,2-dimethoxyethyl)-3,5-dimethyl-1H-pyrazol-4-yl]-, pinacol ester
EINECS	Contact for details

Quality Control

Our 1-(2,2-Dimethoxy-Ethyl)-3,5-Dimethyl-4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our production adheres to cGMP guidelines where applicable, ensuring reliable consistency and traceability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place. For long-term storage, it is recommended to keep the product under an inert atmosphere (e.g., nitrogen or argon) at temperatures between 2°C and 8°C to maintain optimal stability. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.