Description

3-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyrazol-1-Ylmethyl]-Pyridine is a high-value, functionalized pyridine derivative containing a protected boronic ester group, making it a critical advanced pharmaceutical intermediate and versatile building block for modern organic synthesis. Its core value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex carbon-carbon bonds. This compound is essential for researchers and manufacturers in medicinal chemistry, agrochemical development, and materials science who require precise molecular construction for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other targeted therapies.
• Medicinal Chemistry & Drug Discovery: Used in high-throughput screening libraries and for the structure-activity relationship (SAR) optimization of lead compounds.
• Agrochemical Synthesis: Intermediate for creating novel herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science & OLED Development: Serves as a precursor for synthesizing organic semiconductors, light-emitting materials, and other functional polymers.
• Ligand Synthesis for Catalysis: Used to prepare sophisticated pyridine-based ligands for transition metal catalysis.
• Bioconjugation & Probe Development: Facilitates the labeling and modification of biomolecules for diagnostic and research applications.

Basic Information

Product Name	3-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyrazol-1-Ylmethyl]-Pyridine
CAS No.	864754-21-2
Molecular Formula	C15H22BN3O2
Molecular Weight	287.17 g/mol
Synonyms	1-((Pyridin-3-yl)methyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 3-((4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl)methyl)pyridine; Pyridine, 3-[[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazol-1-yl]methyl]-; 3-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazol-1-ylmethyl)pyridine; Boronic acid, B-[1-[(3-pyridinyl)methyl]-1H-pyrazol-4-yl]-, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Pyrazol-1-Ylmethyl]-Pyridine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support compliance with REACH and other global regulatory frameworks as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere (e.g., nitrogen or argon) to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 3.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.