Description

4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1-Thiophen-2-Ylmethyl-1H-Pyrazole is a high-value, functionalized pyrazole derivative containing a pinacol boronate ester group, making it a versatile building block for modern synthetic chemistry. This compound is specifically engineered to serve as a key intermediate in the synthesis of complex molecules, particularly through cross-coupling reactions. It is essential for research and development in the pharmaceutical and agrochemical industries, where it is used to create novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A critical precursor in Suzuki-Miyaura cross-coupling reactions for constructing biaryl and heterobiaryl structures found in drug candidates.
• Agrochemical Synthesis: Used in the research and development of new pesticides and herbicides, leveraging its boronate functionality for structural diversification.
• Material Science Research: Serves as a building block for creating organic electronic materials, such as those used in OLEDs and organic semiconductors.
• Chemical Biology & Probe Development: Utilized in the synthesis of molecular probes and inhibitors for studying biological pathways and enzyme functions.
• Catalyst Ligand Synthesis: Acts as a starting material for the preparation of novel nitrogen-containing ligands used in homogeneous catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to fine chemical manufacturers for the production of bespoke compounds and advanced intermediates on a commercial scale.

Basic Information

Product Name	4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1-Thiophen-2-Ylmethyl-1H-Pyrazole
CAS No.	864754-19-8
Molecular Formula	C15H21BN2O2S
Molecular Weight	304.21 g/mol
Synonyms	1-[(Thiophen-2-yl)methyl]-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole; 1-(Thiophen-2-ylmethyl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrazole; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(thiophen-2-ylmethyl)-1H-pyrazole; 864754-19-8; 1H-Pyrazole, 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1-(2-thienylmethyl)-; Pyrazole boronic acid pinacol ester derivative
EINECS	Contact for details

Quality Control

Every batch of 4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1-Thiophen-2-Ylmethyl-1H-Pyrazole is manufactured and tested under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and batch-to-batch consistency. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.