Description

1-Boc-4-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzoyl]-Piperazine is a high-purity, advanced pharmaceutical intermediate featuring a protected piperazine ring and a key boronic ester functional group. This compound is critical for enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in modern medicinal chemistry for constructing complex biaryl structures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and candidate molecules.

Application

• Pharmaceutical Intermediate: A key building block in the research and development of new drug candidates, particularly for kinase inhibitors and other small molecule therapeutics.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic ester coupling partner for the formation of carbon-carbon bonds between aromatic rings.
• Agrochemical Synthesis: Used in the creation of advanced active ingredients for crop protection products.
• Material Science Research: Employed in the development of organic electronic materials and functional polymers requiring specific piperazine-based architectures.
• Protecting Group Strategy: The tert-butoxycarbonyl (Boc) group allows for selective manipulation of the piperazine nitrogen during multi-step synthetic sequences.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	1-Boc-4-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzoyl]-Piperazine
CAS No.	864754-13-2
Molecular Formula	C22H33BN2O5
Molecular Weight	416.32 g/mol
Synonyms	1-Boc-4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)piperazine; 4-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl)piperazine-1-carboxylic acid tert-butyl ester; tert-Butyl 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]piperazine-1-carboxylate; 1-(tert-Butoxycarbonyl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoyl]piperazine; BOC-Piperazine-Boronic Ester Pinacol Ester
EINECS	Contact for details

Quality Control

Our 1-Boc-4-[4-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Benzoyl]-Piperazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP guidelines where applicable, ensuring material integrity for demanding research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.