Description

2-[2-([1,3]Dioxolan-2-Ylmethoxy)-Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is a high-value, protected boronic ester derivative, a critical intermediate in modern synthetic organic chemistry. Its primary value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials research. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and OLED materials industries, where it facilitates the efficient and selective synthesis of complex biaryl and heterobiaryl structures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing biaryl motifs.
• Suzuki-Miyaura Cross-Coupling Reagent: Enables palladium-catalyzed coupling with aryl halides to construct complex molecular architectures with high efficiency and functional group tolerance.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific biaryl linkages.
• Advanced Materials Research: Serves as a precursor in the development of organic light-emitting diodes (OLEDs), liquid crystals, and conductive polymers.
• Chemical Biology & Proteomics: Can be utilized in the synthesis of molecular probes and bioconjugates for target identification and binding studies.
• Academic & Contract Research: A valuable reagent for methodology development and complex molecule synthesis in university and CRO laboratory settings.

Basic Information

Item	Details
Product Name	2-[2-([1,3]Dioxolan-2-Ylmethoxy)-Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane
CAS No.	864754-12-1
Molecular Formula	C₁₈H₂₇BO₅
Molecular Weight	334.22 g/mol
Synonyms	2-(2-((1,3-Dioxolan-2-ylmethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; [2-(2-([1,3]Dioxolan-2-ylmethoxy)phenyl)]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(2-((1,3-Dioxolan-2-ylmethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; Boronic acid, B-[2-[(1,3-dioxolan-2-ylmethoxy)phenyl]]-4,4,5,5-tetramethyl-1,3,2-dioxaborolane ester; Protected Boronic Ester Intermediate; Aryl Boronic Ester with Acetal Protection.
EINECS	Contact for details

Quality Control

Our 2-[2-([1,3]Dioxolan-2-Ylmethoxy)-Phenyl]-4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolane is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and structural integrity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as specified on the label. This material is hygroscopic (moisture-sensitive); containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.