Description

4,4,5,5-Tetramethyl-2-[2-(2,2,2-Trifluoro-Ethoxy)-Phenyl]-[1,3,2]Dioxaborolane is a specialized organoboron reagent, specifically a pinacol boronic ester, featuring a trifluoroethoxy-substituted aromatic ring. This compound is a critical building block in modern synthetic chemistry, enabling efficient carbon-carbon and carbon-heteroatom bond formation. It is primarily utilized by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries for the synthesis of complex molecules and active ingredients.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key reagent for palladium-catalyzed cross-coupling to create biaryl structures, a common motif in pharmaceuticals and organic electronics.
• Pharmaceutical Intermediate Synthesis: Serves as a versatile building block for constructing drug candidates, particularly those requiring fluorinated aromatic systems for enhanced metabolic stability and bioavailability.
• Agrochemical Active Ingredient Development: Used in the research and production of novel herbicides, fungicides, and insecticides where the trifluoroethoxy group can impart specific biological activity.
• Material Science & OLED Precursors: Employed in the synthesis of organic light-emitting diode (OLED) materials and other advanced organic electronic components.
• Medicinal Chemistry & Drug Discovery: Facilitates rapid analog synthesis and structure-activity relationship (SAR) studies in lead optimization programs.
• Chemical Biology & Probe Development: Acts as a handle for bioconjugation or as a precursor for bioactive probes used in biochemical assays.

Basic Information

Product Name	4,4,5,5-Tetramethyl-2-[2-(2,2,2-Trifluoro-Ethoxy)-Phenyl]-[1,3,2]Dioxaborolane
CAS No.	864754-11-0
Molecular Formula	C14H18BF3O3
Molecular Weight	302.10 g/mol
Synonyms	2-(2-(2,2,2-Trifluoroethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; [2-(2,2,2-Trifluoroethoxy)phenyl]boronic acid pinacol ester; 2-(2-Trifluoroethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(2-(Trifluoroethoxy)phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 864754-11-0; Pinacol [2-(2,2,2-trifluoroethoxy)phenyl]boronate
EINECS	Contact for details

Quality Control

Our production of 4,4,5,5-Tetramethyl-2-[2-(2,2,2-Trifluoro-Ethoxy)-Phenyl]-[1,3,2]Dioxaborolane adheres to stringent quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes comprehensive analysis, including purity assay and impurity profiling. Certificates of Analysis (COA) detailing specific results are provided with every shipment. We support compliance with relevant regulatory frameworks for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (NMR)	Conforms
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.