Description

1-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Thiophen-2-Yl]-Ethanone is a high-value organoboron building block, specifically a thiophene-substituted pinacol boronic ester, essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology in pharmaceutical and advanced materials research. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) and drug candidates, particularly those containing thiophene or biaryl motifs.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring specific heterocyclic structures.
• Material Science & Organic Electronics: Serves as a precursor for conjugated polymers and small molecules used in organic light-emitting diodes (OLEDs), organic photovoltaics (OPVs), and field-effect transistors (OFETs).
• Chemical Research & Development: A versatile reagent in academic and industrial labs for methodology development and the construction of complex, functionalized organic molecules.
• Ligand & Catalyst Preparation: Employed in the synthesis of specialized ligands and organometallic catalysts for asymmetric synthesis and other catalytic processes.

Basic Information

Product Name	1-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Thiophen-2-Yl]-Ethanone
CAS No.	864754-06-3
Molecular Formula	C12H17BO3S
Molecular Weight	252.14 g/mol
Synonyms	2-Acetyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)thiophene; 3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-acetylthiophene; 1-[3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-thienyl]ethanone; 2-Acetylthiophene-3-boronic acid pinacol ester; Thiophene-3-boronic acid, 2-acetyl-, pinacol ester; 864754-06-3; (2-Acetyl-3-thienyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 1-[3-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-Thiophen-2-Yl]-Ethanone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for demanding research and scale-up applications. Each lot undergoes comprehensive analytical characterization including HPLC, NMR (1H, 13C, 11B), and GC/MS to confirm identity and purity. Certificates of Analysis (COA) with full specification data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under an inert atmosphere (argon or nitrogen) for prolonged storage or when opening the container to prevent hydrolysis and maintain reactivity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.