Description

5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile is a high-value, multi-functional boronic ester derivative that serves as a critical synthetic intermediate. Its molecular architecture, featuring both a bromo substituent and a protected boronic acid group, makes it an indispensable building block for constructing complex heterocyclic systems. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for advanced cross-coupling reactions and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for the synthesis of novel drug candidates, particularly in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging its ability to introduce complex pyridine-based scaffolds.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs and charge-transport molecules, due to its electron-deficient picolinonitrile core.
• Chemical Biology Probes: Serves as a versatile handle for bioconjugation and the creation of molecular probes for target identification and validation studies.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client R&D.

Basic Information

Product Name	5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile
CAS No.	863868-53-5
Molecular Formula	C₁₃H₁₆BBrN₂O₂
Molecular Weight	323.00 g/mol
Synonyms	5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-cyanopyridine; 2-Cyano-5-bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 5-Bromo-3-(pinacolatoboryl)picolinonitrile; 5-Bromo-3-(pinacolboronato)picolinonitrile; 5-Bromo-3-(pinacolboryl)-2-pyridinecarbonitrile; 5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridinecarbonitrile; 863868-53-5
EINECS	Contact for details

Quality Control

Every batch of 5-Bromo-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)picolinonitrile is manufactured and tested under a strict quality management system. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged storage or when opening the container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.