Description

1,5-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-2-carbonitrile is a high-value, multi-functional organic building block that combines a pyrrole core with a boronic ester pinacol ester protecting group and a nitrile functionality. This compound matters for its versatility as a key intermediate in modern synthetic chemistry, particularly in cross-coupling reactions to construct complex molecular architectures. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A crucial building block in the synthesis of active pharmaceutical ingredients (APIs) via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides requiring complex heterocyclic structures.
• Material Science Research: Serves as a precursor for the development of organic electronic materials, such as organic light-emitting diodes (OLEDs) and conductive polymers.
• Chemical Biology & Proteomics: Employed as a versatile handle for bioconjugation and the synthesis of molecular probes and inhibitors.
• Academic & Industrial R&D: A valuable reagent for methodology development and the construction of complex, functionalized pyrrole derivatives in organic synthesis.
• Ligand & Catalyst Development: Used to synthesize novel nitrogen-containing ligands for metal catalysis.

Basic Information

Product Name	1,5-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-2-carbonitrile
CAS No.	863868-49-9
Molecular Formula	C13H19BN2O2
Molecular Weight	246.11 g/mol
Synonyms	3-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1,5-dimethyl-1H-pyrrole-2-carbonitrile; 1,5-Dimethyl-3-(tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-2-carbonitrile; 1,5-Dimethyl-3-(pinacolatoboryl)-1H-pyrrole-2-carbonitrile; 2-Cyano-1,5-dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyrrole; 1H-Pyrrole-2-carbonitrile, 1,5-dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 863868-49-9; Boronic acid, B-(2-cyano-1,5-dimethyl-1H-pyrrol-3-yl)-, pinacol ester
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Quality Control

Our 1,5-Dimethyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrrole-2-carbonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is light-sensitive (store away from light). Keep container tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.