Description

2-Chloro-5-Cyanophenyl Boronic Acid Pinacol Ester is a high-purity, synthetically valuable boronic ester derivative. This compound serves as a critical protected intermediate in modern cross-coupling reactions, enabling the precise construction of complex molecules. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for the synthesis of novel active ingredients and functional compounds.

Application

• Suzuki-Miyaura Cross-Coupling Reactions: A key protected boronate reagent for constructing biaryl and heterobiaryl scaffolds in medicinal chemistry.
• Pharmaceutical Intermediate: Used in the research and development of active pharmaceutical ingredients (APIs), particularly those containing chlorinated and cyanated aromatic systems.
• Agrochemical Synthesis: Serves as a building block for creating novel herbicides, fungicides, and insecticides with specific activity profiles.
• Material Science Research: Employed in the synthesis of organic electronic materials, such as ligands for OLEDs or molecular wires.
• Chemical Biology Probes: Useful for synthesizing tagged molecules or inhibitors for proteomics and target identification studies.
• Custom Synthesis and Contract Manufacturing: A valuable starting material for custom synthesis projects requiring specific functionalized aryl boronate derivatives.

Basic Information

Product Name	2-Chloro-5-Cyanophenyl Boronic Acid Pinacol Ester
CAS No.	863868-30-8
Molecular Formula	C₁₃H₁₅BClNO₂
Molecular Weight	263.53 g/mol
Synonyms	2-Chloro-5-cyanophenylboronic acid pinacol ester; (2-Chloro-5-cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-Chloro-5-cyanobenzeneboronic acid pinacol ester; 5-Cyano-2-chlorophenylboronic acid pinacol ester; Pinacol (2-chloro-5-cyanophenyl)boronate; 863868-30-8; B-(2-Chloro-5-cyanophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane
EINECS	Contact for details

Quality Control

Our 2-Chloro-5-Cyanophenyl Boronic Acid Pinacol Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system supports compliance with cGMP and ICH guidelines for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under inert atmosphere (e.g., nitrogen or argon) for prolonged use or storage to maintain optimal stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.