Description

2-Bromo-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide is a high-value, multi-functional chemical intermediate featuring both a bromoacetamide group and a pinacol boronate ester. This compound is essential for facilitating advanced cross-coupling reactions, enabling the precise construction of complex molecular architectures. It is primarily sought after by research scientists and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for applications in drug discovery, catalyst development, and organic synthesis.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs) via Suzuki-Miyaura cross-coupling reactions.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides by introducing the acetamide-boronate moiety into target structures.
• Material Science: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials.
• Chemical Biology & Proteomics: Employed as a versatile handle for bioconjugation and the development of activity-based probes and inhibitors.
• Catalyst & Ligand Synthesis: Utilized to construct novel bidentate or tridentate ligands for transition metal catalysis.
• Academic & Contract Research: A critical reagent for methodological development in organic synthesis and medicinal chemistry programs.

Basic Information

Product Name	2-Bromo-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide
CAS No.	863118-14-3
Molecular Formula	C14H19BBrNO3
Molecular Weight	340.02 g/mol
Synonyms	2-Bromo-N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]acetamide; 4-(2-Bromoacetamido)phenylboronic acid pinacol ester; N-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-2-bromoacetamide; 2-Bromoacetamide, N-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-; 4-Acetamidophenylboronic acid pinacol ester, 2-bromo-; Bromoacetamide Boronate Ester; 863118-14-3; Bromo-PBA pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Bromo-N-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)acetamide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) with full characterization data are provided to guarantee compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.