Description

3-Amino-5-Bromo-4-Hydroxy-Benzonitrile is a high-purity, multi-functional benzonitrile derivative that serves as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring amino, bromo, and hydroxy substituents, makes it a versatile intermediate for constructing complex heterocyclic systems and functionalized aromatic compounds. This compound is essential for research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop new active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly for kinase inhibitors, antiviral agents, and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and plant growth regulators, leveraging its halogen and nitrile functionality.
• Dye & Pigment Manufacturing: Serves as a building block for creating specialized azo dyes and high-performance pigments due to its aromatic amine and hydroxy groups.
• Material Science Research: Employed in the development of organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) for electronic and photonic applications.
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination.
• Chemical Biology Probes: Utilized as a scaffold for synthesizing fluorescent tags, affinity labels, and other molecular probes for biological research.

Basic Information

Product Name	3-Amino-5-Bromo-4-Hydroxy-Benzonitrile
CAS No.	862730-24-3
Molecular Formula	C7H5BrN2O
Molecular Weight	213.03 g/mol
Synonyms	5-Bromo-4-hydroxy-3-aminobenzonitrile; 3-Amino-5-bromo-4-hydroxybenzonitrile; 4-Hydroxy-3-amino-5-bromobenzonitrile; 2-Amino-6-bromo-3-cyano-phenol; 2-Cyano-4-bromo-5-aminophenol; Benzonitrile, 3-amino-5-bromo-4-hydroxy-; 862730-24-3
EINECS	Contact for details

Quality Control

Our 3-Amino-5-Bromo-4-Hydroxy-Benzonitrile is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes data from HPLC, NMR, and other relevant spectroscopic methods. Our quality commitment ensures the material meets the stringent requirements for research and cGMP-grade synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.