Description

1H-Indazole-5-Boronic Acid Pinacol Ester is a high-purity, advanced pharmaceutical intermediate and versatile building block for organic synthesis. This compound is critical for facilitating Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl and heterobiaryl structures. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, agrochemical, and material science industries for the development of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of drug candidates, particularly those containing the indazole pharmacophore for oncology, CNS, and anti-inflammatory applications.
• Agrochemical Research: Used in creating novel herbicides, fungicides, and insecticides through palladium-catalyzed coupling to introduce complex heterocyclic systems.
• Material Science: Serves as a precursor for organic electronic materials, such as OLEDs and semiconductors, where precise molecular architecture is required.
• Chemical Biology & Proteomics: Employed in the development of molecular probes and enzyme inhibitors for target identification and validation studies.
• Academic & Contract Research: Essential reagent for methodological development in synthetic organic chemistry and catalysis research.
• Scale-up & Process Chemistry: Suitable for use in pilot plant and commercial-scale manufacturing processes for active pharmaceutical ingredients (APIs).

Basic Information

Product Name	1H-Indazole-5-Boronic Acid Pinacol Ester
CAS No.	862723-42-0
Molecular Formula	C₁₄H₁₉BN₂O₂
Molecular Weight	258.13 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 1H-Indazole-5-boronic acid, pinacol ester; 5-(Pinacolboryl)-1H-indazole; 862723-42-0; Indazole-5-boronic acid pinacol ester; 5-Indazoleboronic Acid Pinacol Ester; 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolanyl)-1H-indazole
EINECS	Contact for details

Quality Control

Our 1H-Indazole-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and LC-MS, to ensure high chemical purity and identity. Certificates of Analysis (COA) with full analytical data are provided for every shipment, ensuring traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.