Description

6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole is a high-purity, advanced pharmaceutical intermediate and versatile building block in organic synthesis. This compound is critical for enabling efficient cross-coupling reactions, particularly the Suzuki-Miyaura reaction, which is fundamental to modern drug discovery and materials science. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries to construct complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel active pharmaceutical ingredients (APIs), especially in oncology and CNS drug discovery programs.
• Suzuki-Miyaura Cross-Coupling: The boronic ester pinacol group serves as a stable, reactive handle for forming carbon-carbon bonds with aryl/heteroaryl halides, a cornerstone reaction in medicinal chemistry.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides that require the indazole-boronate scaffold.
• Material Science: Employed in the synthesis of organic electronic materials, such as OLEDs and semiconductors, where precise molecular structure is essential.
• Chemical Biology & Proteomics: Acts as a versatile linker or tag in the development of chemical probes and affinity reagents for target identification.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole
CAS No.	861905-87-5
Molecular Formula	C₁₃H₁₇BN₂O₂
Molecular Weight	244.10 g/mol
Synonyms	1H-Indazole, 6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 6-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 6-(Tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-indazole; 6-Indazoleboronic acid pinacol ester; 6-Pinacolboryl-1H-indazole; 6-(Pinacolatoboryl)-1H-indazole; 6-Boronopinacolatoboryl-1H-indazole; 6-(4,4,5,5-Tetramethyl-[1,3,2]dioxaborolan-2-yl)-1H-indazole
EINECS	Contact for details

Quality Control

Our 6-(4,4,5,5-Tetramethyl-[1,3,2]Dioxaborolan-2-Yl)-1H-Indazole is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and scale-up. All products undergo rigorous analytical testing, including HPLC, NMR, and MS, to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each batch to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Assay (NMR)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.