Description

Ethyl 2-[4-(Trifluoromethyl)anilino]-1,3-thiazole-4-carboxylate is a high-value, synthetically versatile heterocyclic organic compound featuring a thiazole core substituted with an ethyl ester and a 4-(trifluoromethyl)anilino group. This structure makes it a critical pharmaceutical intermediate and a valuable building block in advanced organic synthesis, particularly for developing novel active ingredients. It is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating compounds with targeted biological or physical properties.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting specific enzymes or receptors where the trifluoromethyl group enhances metabolic stability and bioavailability.
• Agrochemical Research: Serves as a building block for developing new herbicides, fungicides, or insecticides, leveraging the thiazole moiety's bioactivity.
• Organic Synthesis Building Block: Used in medicinal and combinatorial chemistry to construct complex heterocyclic libraries for high-throughput screening.
• Material Science Precursor: Potential intermediate in the synthesis of specialty chemicals, dyes, or functional materials requiring specific electronic properties.
• Academic & Contract Research: Employed in university and CRO laboratories for fundamental research on heterocyclic chemistry and structure-activity relationships (SAR).

Basic Information

Product Name	Ethyl 2-[4-(Trifluoromethyl)anilino]-1,3-thiazole-4-carboxylate
CAS No.	860783-84-2
Molecular Formula	C13H11F3N2O2S
Molecular Weight	316.30 g/mol
Synonyms	Ethyl 2-((4-(trifluoromethyl)phenyl)amino)thiazole-4-carboxylate; 4-Thiazolecarboxylic acid, 2-[[4-(trifluoromethyl)phenyl]amino]-, ethyl ester; 2-[(4-Trifluoromethylphenyl)amino]-1,3-thiazole-4-carboxylic acid ethyl ester; Ethyl 2-[(4-trifluoromethylphenyl)amino]thiazole-4-carboxylate; 860783-84-2; Ethyl 2-(4-trifluoromethylanilino)thiazole-4-carboxylate
EINECS	Contact for details

Quality Control

Our production of Ethyl 2-[4-(Trifluoromethyl)anilino]-1,3-thiazole-4-carboxylate adheres to stringent quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality systems are designed to support cGMP requirements for pharmaceutical intermediates, ensuring traceability and reliability for our global B2B clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed to minimize exposure to atmospheric humidity. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.