Description

(E)-3-(Dimethylamino)-1-[2-Fluoro-4-(Trifluoromethyl)Phenyl]-2-Propen-1-One is a high-value fluorinated organic intermediate characterized by its unique α,β-unsaturated ketone (enone) structure. This compound is critical for its role as a versatile building block in advanced organic synthesis, particularly in the construction of complex molecules. It is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates, especially those targeting central nervous system (CNS) disorders or possessing anti-inflammatory properties.
• Agrochemical Synthesis: Used in the research and development of new-generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl and fluoro substituents.
• Material Science Research: Acts as a monomer or cross-linking agent in the development of specialty polymers and advanced organic materials with specific optical or electronic properties.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and inhibitors for studying enzyme mechanisms and biological pathways.
• Ligand and Catalyst Development: Utilized as a starting material for creating novel ligands and organocatalysts used in asymmetric synthesis.

Basic Information

Product Name	(E)-3-(Dimethylamino)-1-[2-Fluoro-4-(Trifluoromethyl)Phenyl]-2-Propen-1-One
CAS No.	860649-00-9
Molecular Formula	C₁₂H₁₁F₄NO
Molecular Weight	261.22 g/mol
Synonyms	1-[2-Fluoro-4-(trifluoromethyl)phenyl]-3-(dimethylamino)-2-propen-1-one; (E)-3-(Dimethylamino)-1-(2-fluoro-4-(trifluoromethyl)phenyl)prop-2-en-1-one; 2-Propen-1-one, 3-(dimethylamino)-1-[2-fluoro-4-(trifluoromethyl)phenyl]-, (E)-; Enaminone Derivative CAS 860649-00-9; 2-Fluoro-4-trifluoromethyl chalcone derivative; DMAPF Derivative
EINECS	Contact for details

Quality Control

Our (E)-3-(Dimethylamino)-1-[2-Fluoro-4-(Trifluoromethyl)Phenyl]-2-Propen-1-One is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided and can be tailored to meet specific customer requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). Keep away from strong oxidizing agents and bases. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.